Glutethimide, seemed to have several advantages over the older therapeutic agents. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. The use of glutethimide doriden in obstetrics ncbi nih. Glutethimide dependence may be treated by gradual, stepwise reduction of dosage over a period of days or weeks. Glutethimide definition of glutethimide by medical. Subsequent experience with glutethimide indicated that the severity of the abuse potential and withdrawal symptoms. If withdrawal symptoms occur, they may be controlled by readministration of glutethimide, or substitution of pentobarbital, and subsequent gradual withdrawal. Drugs details glutethimide drug class, mechanism of. Websters bibliographic and eventbased timelines are comprehensive in scope, covering virtually all topics, geographic locations and people. Despite this, the history of the development of thalidomide, and of the. The coma induced by large overdoses of glutethimide doriden is similar to that produced by the barbiturates.
Glutethimide poisoning a metabolite contributes to. The ingestion of glutethimide and codeine loads constitutes a form of drug addiction 56, 57. Glutethimide ch15no2 cid 3487 structure, chemical names, physical and chemical. In 1954, glutethimide doriden was introduced into the us market as a safe substitute for barbiturates. Glutethimide is a hypnotic sedative that was introduced by ciba in 1954 as a safe alternative to.
Glutethimide definition is a sedativehypnotic drug ch15no2 that is a derivative of piperidine and has pharmacological properties similar to those of barbiturates. Get a printable copy pdf file of the complete article 796k, or click on a page image below to browse page by page. A hypnotic sedative formerly used as an alternative to barbiturates to treat insomnia. Glutethimide is a hypnotic and sedative agent intended to treat insomnia. My chemistry teacher assigned this book for our class to read so we may better understand the chemicals involved in drugs. Predicted data is generated using the us environmental protection agencys episuite. A complete guide to their history, chemistry, use, and abuse. Glutethimide dose, plasma concentration, and history of coingestion of. Before long, however, it had become clear that glutethimide was just as likely to cause addiction and caused similar withdrawal symptoms. Glutethimide definition of glutethimide by merriamwebster. List of psychotropic substances under international control pdf. As it easily induces addiction and withdrawal syndrome, glutethimide is one of the less frequently prescribed hypnosedatives. The normal hypnotic dose in adults lies between 250500 mg orally. The clinical course of the glutethimideintoxicated patient, however, is often complex.
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